منابع مشابه
Rasburicase‐induced methemoglobinemia: case report, literature review, and proposed treatment algorithm
Rasburicase for the treatment of tumor lysis syndrome has been associated with hemolytic anemia and methemoglobinemia, usually in patients with G6PD deficiency. Risks and benefits should be considered prior to use of rasburicase in at-risk patients. Methylene blue will worsen the hemolytic anemia in G6PD deficiency and should be avoided.
متن کاملRasburicase-Induced Methemoglobinemia in a Patient with Aggressive Non-Hodgkin’s Lymphoma
BACKGROUND Rasburicase is a recombinant urate oxidase enzyme that converts uric acid to allantoin (an inactive and soluble metabolite that is readily excreted in urine). It is used for the management of tumor lysis syndrome (TLS) in cancer patients receiving chemotherapy. Although rasburicase is a generally safe and effective treatment, it can be associated with the rare and potentially severe ...
متن کاملExchange transfusion as treatment for rasburicase induced methemoglobinemia in a glucose-6-phosphate dehydrogenase deficient patient.
To the Editor: A recent letter in this journal described methemoglobinemia and hemolysis due to rasburicase in a patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency [1]. We would like to report on the management of a patient with rasburicase induced methemoglobinemia and G6PD deficiency. DS is a 12-year-old Laotian male who presented with a white blood cell count of 533,900/mm (89%...
متن کاملRasburicase-induced fatal respiratory arrest?
Urate oxidase is an endogenous enzyme found in most mammals but not in humans. Urate oxidase catalyzes the enzymatic oxidation of uric acid into allantoin, a metabolite that is 5–10 times more soluble in urine than uric acid. With complementary DNA technology it is possible to produce large quantities of the pure recombinant protein [1]. Rasburicase (RS), a recombinant form of urate oxidase, ha...
متن کاملDrug-induced methemoglobinemia.
The normal presentation of a patient with a drug induced methemoglobinemia is a low pulse oximetry (SpO2) reading, usually in the mid 80% range, while having a very high PaO2 on an arterial blood gas (ABG)1. We present a case where the initial ABG showed a very high PaO2 and a metabolic alkalosis while the SpO2 fluctuated (85% 99%). Those findings combined with hemodynamic instability complicat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cureus
سال: 2021
ISSN: 2168-8184
DOI: 10.7759/cureus.14406